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Toxic megacolontotal or segmental nonobstructive dilatation of the colon with systemic toxicity in patients with IBD or infectious colitis Laboratory values of acute phase reactants, including the erythrocyte sedimentation rate and C- reactive protein, can be increased but may also be normal in mildly active disease

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When this pattern is observed consistently across multiple injections, copper sensitivity is the first thing evaluated and the primary reason protocols are adjusted or discontinued

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